 | Название: | Role of TCF in body axis formation: Discovery of a Dual Action of XTCF-3 in Xenopus Body Axis Formation |
| Автор: | Miranda Molenaar | |
| Год: | 2010 | |
| ISBN: | 3838320522 | |
| Количество страниц: | 80 | |
| Цена: | 7 132 руб. | |
| Описание: | A novel role of TCF family in body axis formation. Revolutionary high impact discoveries are described, elucidating the missing link in the Wnt pathway and protein-TCF combinations with dual functions. By studying the primary axis formation of Xenopus laevis, it was firstly shown that, in combination with beta-catenin, TCF acts as a potent activator of proto-oncogenes. Secondly, it was discovered that in combination with the Groucho family of proteins, TCF acts as suppressor of oncogene transcription. Stronlgy suggesting that TCF controls oncogene transcription in a dual fashion. These discoveries contributed to the origination of a major area of cancer research and opened multiple angles for cancer therapy development. |
Структура:
Списки:
Сложность материала:
Величины и единицы:
Книги Список книг
Biomolecular Crystallography: Principles, Practice, and Application to Structural Biology Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and ...
Биологическая химия Учебник состоит из четырёх частей, включающих 15 глав, в которых изложены вопросы ...
Химия билирубина и его аналогов В настоящей монографии изложены результаты фундаментальных и прикладных ...