Histone H1 glycation and rutin metabolites as glycation inhibitors: Nuclear protein glycation in vivo and novel natural product AGE inhibitors

Главная /   — Далее   Книги / Histone H1 glycation and rutin metabolites as glycation inhibitors: Nuclear protein glycation in vivo and novel natural product AGE inhibitors


Daniel Cervantes-Laurean, Srinath Pashikanti / Histone H1 glycation and rutin metabolites as glycation inhibitors: Nuclear protein glycation in vivo and novel natural product AGE inhibitors / Protein glycation, induced by hyperglycemia, is implicated in the appearance of diabetic complications and the aging ...Название:Histone H1 glycation and rutin metabolites as glycation inhibitors: Nuclear protein glycation in vivo and novel natural product AGE inhibitors
Автор:Daniel Cervantes-Laurean, Srinath Pashikanti
Год:2010
ISBN:363921224X
Количество страниц:52
Цена:7 308 руб.
Описание:Protein glycation, induced by hyperglycemia, is implicated in the appearance of diabetic complications and the aging process. Glycation involves the non-enzymatic reaction between sugars and protein amino groups that lead to formation of advanced glycation end products (AGEs). When aminoguanidine, a proven AGE inhibitor, was tested as an anti-diabetic drug in clinical trials showed critical side effects, which suggested a need for improved AGE inhibitors. A protein glycation model included histone H1 and glyoxal or methylglyoxal since it allowed to distinguish AGE inhibitors from antioxidants. This book describes the findings of Dr Cervantes and graduate student, Srinath Pashikanti, of novel natural product AGE inhibitors and the in vivo modification of nuclear proteins, histone H1, with AGE adducts. Rutin metabolic derivatives were tested as AGEs inhibitors since rutin, a flavonoid consumed in fruits and vegetables, is metabolized in the gut. These results suggest effective...

Структура:

Списки:

Сложность материала:

Величины и единицы:


Книги Список книг
Математические модели морфогенеза / Автором предлагаемого курса лекций по математическим моделям морфогенеза является известный французский математик и философ, крупнейший специалист в области алгебраической и дифференциальной топологии, основоположник математической теории катастроф, Рене Том, получивший в 1956 году философскую премиМатематические модели морфогенеза
Автором предлагаемого курса лекций по математическим моделям морфогенеза ...
Review of Medical Microbiology and Immunology / To put your preparation for USMLE Step 1 and course exams on the fast track, only one resource will do: «Review of Medical Microbiology and Immunology». Completely updated throughout, the Eleventh Edition presents a high-yield review of the basic and clinical aspects of bacteriology, virology, mycolReview of Medical Microbiology and Immunology
To put your preparation for USMLE Step 1 and course exams on the fast track, only one resource will do: «Review of Medical Microbiology and ...
NMR Studies of Structural Motifs: Protein Folding and Ligand Binding / NMR of Structural Motifs: The agrin G3 domain is critical in development and maintenance of the neuromuscular junction. G3 binds -dystroglycan and initiates acetylcholine receptor clustering on myotube membranes. Using NMR spectroscopy, we show both active B8 and inactive B0 isoforms binding sialic NMR Studies of Structural Motifs: Protein Folding and Ligand Binding
NMR of Structural Motifs: The agrin G3 domain is critical in development and maintenance of the neuromuscular junction. G3 binds -dystroglycan and ...
Молекулярная биология / Книга посвящена ряду актуальных проблем молекулярной биологии (молекулярный механизм и биохимия сокращения мышцы, ультраструктура нервного волокна и молекулярные процессы, связанные с возбуждением нерва, структура белка и мукополисахаридов). Она содержит много интересных фактов и заслуживающих внимаМолекулярная биология
Книга посвящена ряду актуальных проблем молекулярной биологии (молекулярный ...