Histone H1 glycation and rutin metabolites as glycation inhibitors: Nuclear protein glycation in vivo and novel natural product AGE inhibitors

Главная /   — Далее   Книги / Histone H1 glycation and rutin metabolites as glycation inhibitors: Nuclear protein glycation in vivo and novel natural product AGE inhibitors


Daniel Cervantes-Laurean, Srinath Pashikanti / Histone H1 glycation and rutin metabolites as glycation inhibitors: Nuclear protein glycation in vivo and novel natural product AGE inhibitors / Protein glycation, induced by hyperglycemia, is implicated in the appearance of diabetic complications and the aging ...Название:Histone H1 glycation and rutin metabolites as glycation inhibitors: Nuclear protein glycation in vivo and novel natural product AGE inhibitors
Автор:Daniel Cervantes-Laurean, Srinath Pashikanti
Год:2010
ISBN:363921224X
Количество страниц:52
Цена:7 308 руб.
Описание:Protein glycation, induced by hyperglycemia, is implicated in the appearance of diabetic complications and the aging process. Glycation involves the non-enzymatic reaction between sugars and protein amino groups that lead to formation of advanced glycation end products (AGEs). When aminoguanidine, a proven AGE inhibitor, was tested as an anti-diabetic drug in clinical trials showed critical side effects, which suggested a need for improved AGE inhibitors. A protein glycation model included histone H1 and glyoxal or methylglyoxal since it allowed to distinguish AGE inhibitors from antioxidants. This book describes the findings of Dr Cervantes and graduate student, Srinath Pashikanti, of novel natural product AGE inhibitors and the in vivo modification of nuclear proteins, histone H1, with AGE adducts. Rutin metabolic derivatives were tested as AGEs inhibitors since rutin, a flavonoid consumed in fruits and vegetables, is metabolized in the gut. These results suggest effective...

Структура:

Списки:

Сложность материала:

Величины и единицы:


Книги Список книг
Molecular Biology of the Cell: The Problems Book / The Problems Book helps students appreciate the ways in which experiments and simple calculations can lead to an understanding of how cells work by introducing the experimental foundation of cell and molecular biology. Each chapter will review key terms, test for understanding basic concepts, and poMolecular Biology of the Cell: The Problems Book
The Problems Book helps students appreciate the ways in which experiments and simple calculations can lead to an understanding of how cells work by ...
Прикладная молекулярная биология. Изд.2 / В учебном пособии изложены основы молекулярной биологии, а также направления приложения закономерностей молекулярной биологии для практического использования. Рассмотрены системная организация живого вещества на биосферном и молекулярном уровнях, структурная организация макромолекул, функции биополиПрикладная молекулярная биология. Изд.2
В учебном пособии изложены основы молекулярной биологии, а также направления ...
Koneman’s Color Atlas and Textbook of Diagnostic Microbiology / Long considered the definitive work in its field, this new edition presents all the principles and practices readers need for a solid grounding in all aspects of clinical microbiology—bacteriology, mycology, parasitology, and virology. Tests are presented according to the Clinical and Laboratory StaKoneman’s Color Atlas and Textbook of Diagnostic Microbiology
Long considered the definitive work in its field, this new edition presents all the principles and practices readers need for a solid grounding in all ...
Молекулярная биология процессов развития / Книга представляет собой полную сводку современных знаний о молекулярных основах процессов развития. В ней рассматриваются изменения содержания, состава и скорости синтеза ДНК, РНК и белков на двух основных этапах развития — оогенеза и эмбриогенеза. Книга предназначена для специалистов по молекулярнМолекулярная биология процессов развития
Книга представляет собой полную сводку современных знаний о молекулярных ...