Б. Активация цитотоксических Т-клеток

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Инфицированная клетка презентирует с помощью белков ГКГС класса I небольшой чужеродный пептид, который может связываться с поверхностью Т-клетки с помощью Т-клеточных рецепторов. Цитотоксическая Т-клетка несёт на поверхности кроме Т-клеточных рецепторов также белок CD8, связывающий комплекс из молекул ГКГС и чужеродного пептида. Это активирует цитотоксическую Т-клетку и делает её способной разрушать инфицированную клетку. В рамке на рисунке показан пептидпрезентирующий домен молекулы ГКГС класса I со связанным чужеродным пептидом (на схеме фиолетового цвета).


Ткани и органы. Иммунная система / Белки главного комплекса гисто-совместимости

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